PUBLICATIONS

2015 - Present (U.Penn)
Identifying Sequence Perturbations to an Intrinsically Disordered Protein that Determine Its Phase Separation Behavior
AUTHORS: Benjamin Schuster, Gregory L Dignon, Wai Shing Tang, Fleurie Kelley, Aishwarya Kanchi Ranganath, Craig N. Jahnke, Alison G. Simpkins, Roshan M. Regy, Daniel A. Hammer, Matthew C. Good, Jeetain Mittal
In press at PNAS (2020). Preprint on BioRxiv. Link.
SPLIT: Stable Protein Coacervation Using a Light Induced Transition
AUTHORS: Reed, E.H., Schuster, B.S., Good, M.C., Hammer, D.A.
ACS Synthetic Biology 9(3):500-507 (2020). PDF. Link.
Spatiotemporal Patterning of Zygotic Genome Activation in A Model Vertebrate Embryo
AUTHORS: Chen, H., Einstein, L.C., Little, S., Good, M.C.*
​Developmental Cell 49 852-866 (2019). PDF. Link. News
Encapsulation of Hydrophobic Components in Dendrimersomes and Decoration of their Surface with Proteins and Nucleic Acids
AUTHORS: Torre, P., Xiao, Q., Buzzacchera, I., Sherman, S.E., Rahimi, K., Kostina, N.Y., Rodriguez-Emmenegger, C., Möller, M., Wilson, C.J., Klein, M.L.*, Good, M.C.*, Percec, V.*
PNAS.  (2019). PDF. Link. News.
Cell Parts to Complex Processes, From the Bottom Up
AUTHORS: Good M.*, Trepat X.*
Nature 563(7730): 188-189 (2018). PDF. Link
Controllable Protein Phase Separation and Modular Recruitment to Form Responsive Membraneless Organelles
AUTHORS: Schuster, B.S., Reed, E.H., Parthasarathy, R., Jahnke, C.N., Caldwell, R.M., Bermudez J.G., Ramage H.R., Good, M.C.* and Hammer, D.A.* 
Nature Communications 9:2985 (2018). PDF. Link
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Optochemical Control of Protein Localization and Activity Within Cell-Like Compartments
AUTHORS: Caldwell R.M.#, Bermudez J.G.#, Thai D., Aonbangkhen C., Schuster B.S., Courtney T., Deiters A., Hammer D.A., Chenoweth D.M., and Good M.C.*
Biochemistry 57, 2590-2596 (2018). PDF. Pubmed
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Preparation of Cellular Extracts from Xenopus Eggs and Embryos
AUTHORS:  Good M.C.*, Heald R.*
Cold Spring Harbor Protocols (2018). PDF. Pubmed
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Probing the Biology of Cell Boundary Conditions Through Confinement of Xenopus Cell-Free Cytoplasmic Extracts
AUTHORS:  Bermudez J.G., Chen H., Einstein L.C., Good M.C.*
Genesis 55 (2017). PDF.  Pubmed
Size Regulation: Big Insights from Little Cells
AUTHORS:  Chen H., and Good M.C.*
Developmental Cell  37, 392-394 (2016). PDF.  Pubmed
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Encapsulation of Xenopus Egg and Embryo Extract Spindle Assembly Reactions In Synthetic Cell-like Compartments with Tunable Size
AUTHORS:  Good M.C.*
Methods in Molecular Biology  1413, 87-108 (2016). PDF.  Pubmed
Turn Up the Volume: Uncovering Nucleus Size Control Mechanisms
AUTHORS:  Good M.C.*
Developmental Cell  33, 496-497 (2015).  PDF.  Pubmed
Previous Publications
A Comparative Analysis of Spindle Morphometrics across Metazoans
AUTHORS:  Crowder, M.E., Strzelecka, M., Wilbur, J.D., Good, M.C., von Dassow, G., and Heald, R.
Current Biology  25, 1542-1550 (2015).   PDF.  Pubmed   
 
Cytoplasmic Volume Modulates Spindle Size During Embryogenesis
AUTHORS:  Good, M.C., Vahey, M.D., Skandarajah, A., Fletcher, D.A., and Heald, R.
Science  342, 856-860 (2013).  PDF.  Pubmed
Scaffold proteins: hubs for controlling the flow of cellular information
AUTHORS:  Good, M.C., Zalatan, J.G., and Lim, W.A. 
Science  332, 680-686 (2011).  PDF.  Pubmed
Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB
AUTHORS:  Lombana, T.N., Echols, N., Good, M.C., Thomsen, N.D., Ng, H.L., Greenstein, A.E., Falick, A.M., King, D.S., and Alber, T. 
Structure  18, 1667-1677 (2010).  PDF.  Pubmed
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
AUTHORS:  Mok, J., Kim, P.M., Lam, H.Y., Piccirillo, S., Zhou, X., Jeschke, G.R., Sheridan, D.L., Parker, S.A., Desai, V., Jwa, M., Cameroni, E., Niu, H., Good, M., Remenyi, A., Ma, J.L., Sheu, Y.J., Sassi, H.E., Sopko, R., Chan, C.S., De Virgilio, C., Hollingsworth, N.M., Lim, W.A., Stern, D.F., Stillman, B., Andrews, B.J., Gerstein, M.B., Snyder, M., and Turk, B.E.  
Science Signaling  3, ra12 (2010).  PDF.  Pubmed
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
AUTHORS:  Good, M., Tang, G., Singleton, J., Remenyi, A., and Lim, W.A.
Cell  136, 1085-1097 (2009).  PDF.  Pubmed
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
AUTHORS:  King, N., Westbrook, M.J., Young, S.L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., Marr, M., Pincus, D., Putnam, N., Rokas, A., Wright, K.J., Zuzow, R., Dirks, W., Good, M., … and Rokhsar, D. 
Nature  451, 783-788 (2008).  PDF.  Pubmed
Docking interactions in protein kinase and phosphatase networks
AUTHORS:  Remenyi, A., Good, M.C., and Lim, W.A. 
Current Opinion in Structural Biology  16, 676-685 (2006).  PDF.  Pubmed
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.
AUTHORS:  Bhattacharyya, R.P., Remenyi, A., Good, M.C., Bashor, C.J., Falick, A.M., and Lim, W.A.
Science  311, 822-826 (2006).  PDF.  Pubmed
The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network
AUTHORS:  Remenyi, A., Good, M.C., Bhattacharyya, R.P., and Lim, W.A. 
Molecular Cell  20, 951-962 (2005).  PDF.  Pubmed
Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller
AUTHORS:  Good, M.C., Greenstein, A.E., Young, T.A., Ng, H.L., and Alber, T.
Journal of Molecular Biology  339, 459-469 (2004).  PDF.  Pubmed
An alternate conformation and a third metal in PstP/Ppp, the M. tuberculosis PP2C-Family Ser/Thr protein phosphatase
Pullen, K.E., Ng, H.L., Sung, P.Y., Good, M.C., Smith, S.M., and Alber, T.
Structure  12, 1947-1954 (2004).  PDF.  Pubmed