PUBLICATIONS

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2015 - Present (U.Penn)

Cell Parts to Complex Processes, From the Bottom Up
Good M.*, Trepat X.*
Nature 563(7730): 188-189 (2018). PDF. Link

Controllable Protein Phase Separation and Modular Recruitment to Form Responsive Membraneless Organelles
AUTHORS: Schuster, B.S., Reed, E.H., Parthasarathy, R., Jahnke, C.N., Caldwell, R.M., Bermudez J.G., Ramage H.R., Good, M.C.* and Hammer, D.A.* 
Nature Communications 9:2985 (2018). PDF. Link
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Optochemical Control of Protein Localization and Activity Within Cell-Like Compartments
AUTHORS: Caldwell R.M.*, Bermudez J.G.*, Thai D., Aonbangkhen C., Schuster B.S., Courtney T., Deiters A., Hammer D.A., Chenoweth D.M., and Good M.C.*
Biochemistry 57, 2590-2596 (2018). PDF. Pubmed
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Preparation of Cellular Extracts from Xenopus Eggs and Embryos
AUTHORS:  Good M.C.*, Heald R.*
Cold Spring Harbor Protocols (2018). PDF. Pubmed
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Probing the Biology of Cell Boundary Conditions Through Confinement of Xenopus Cell-Free Cytoplasmic Extracts
AUTHORS:  Bermudez J.G., Chen H., Einstein L.C., Good M.C.*
Genesis 55 (2017). PDF.  Pubmed

Size Regulation: Big Insights from Little Cells
AUTHORS:  Chen H., and Good M.C.*
Developmental Cell  37, 392-394 (2016). PDF.  Pubmed
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Encapsulation of Xenopus Egg and Embryo Extract Spindle Assembly Reactions In Synthetic Cell-like Compartments with Tunable Size
AUTHORS:  Good M.C.*
Methods in Molecular Biology  1413, 87-108 (2016). PDF.  Pubmed

Turn Up the Volume: Uncovering Nucleus Size Control Mechanisms
AUTHORS:  Good M.C.*
Developmental Cell  33, 496-497 (2015).  PDF.  Pubmed

Previous Publications

A Comparative Analysis of Spindle Morphometrics across Metazoans
AUTHORS:  Crowder, M.E., Strzelecka, M., Wilbur, J.D., Good, M.C., von Dassow, G., and Heald, R.
Current Biology  25, 1542-1550 (2015).   PDF.  Pubmed   
 

Cytoplasmic Volume Modulates Spindle Size During Embryogenesis
AUTHORS:  Good, M.C., Vahey, M.D., Skandarajah, A., Fletcher, D.A., and Heald, R.
Science  342, 856-860 (2013).  PDF.  Pubmed

Scaffold proteins: hubs for controlling the flow of cellular information
AUTHORS:  Good, M.C., Zalatan, J.G., and Lim, W.A. 
Science  332, 680-686 (2011).  PDF.  Pubmed

Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB
AUTHORS:  Lombana, T.N., Echols, N., Good, M.C., Thomsen, N.D., Ng, H.L., Greenstein, A.E., Falick, A.M., King, D.S., and Alber, T. 
Structure  18, 1667-1677 (2010).  PDF.  Pubmed

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
AUTHORS:  Mok, J., Kim, P.M., Lam, H.Y., Piccirillo, S., Zhou, X., Jeschke, G.R., Sheridan, D.L., Parker, S.A., Desai, V., Jwa, M., Cameroni, E., Niu, H., Good, M., Remenyi, A., Ma, J.L., Sheu, Y.J., Sassi, H.E., Sopko, R., Chan, C.S., De Virgilio, C., Hollingsworth, N.M., Lim, W.A., Stern, D.F., Stillman, B., Andrews, B.J., Gerstein, M.B., Snyder, M., and Turk, B.E.  
Science Signaling  3, ra12 (2010).  PDF.  Pubmed

The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
AUTHORS:  Good, M., Tang, G., Singleton, J., Remenyi, A., and Lim, W.A.
Cell  136, 1085-1097 (2009).  PDF.  Pubmed

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
AUTHORS:  King, N., Westbrook, M.J., Young, S.L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., Marr, M., Pincus, D., Putnam, N., Rokas, A., Wright, K.J., Zuzow, R., Dirks, W., Good, M., … and Rokhsar, D. 
Nature  451, 783-788 (2008).  PDF.  Pubmed

Docking interactions in protein kinase and phosphatase networks
AUTHORS:  Remenyi, A., Good, M.C., and Lim, W.A. 
Current Opinion in Structural Biology  16, 676-685 (2006).  PDF.  Pubmed

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.
AUTHORS:  Bhattacharyya, R.P., Remenyi, A., Good, M.C., Bashor, C.J., Falick, A.M., and Lim, W.A.
Science  311, 822-826 (2006).  PDF.  Pubmed

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network
AUTHORS:  Remenyi, A., Good, M.C., Bhattacharyya, R.P., and Lim, W.A. 
Molecular Cell  20, 951-962 (2005).  PDF.  Pubmed

Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller
AUTHORS:  Good, M.C., Greenstein, A.E., Young, T.A., Ng, H.L., and Alber, T.
Journal of Molecular Biology  339, 459-469 (2004).  PDF.  Pubmed

An alternate conformation and a third metal in PstP/Ppp, the M. tuberculosis PP2C-Family Ser/Thr protein phosphatase
Pullen, K.E., Ng, H.L., Sung, P.Y., Good, M.C., Smith, S.M., and Alber, T.
Structure  12, 1947-1954 (2004).  PDF.  Pubmed

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