PUBLICATIONS

Pre-prints and manuscripts under review

37. Nascent Transcriptome Reveals Orchestration of Zygotic Genome Activation In Early Embryogenesis 
Chen H., Good, M.C.*
Current Biology, 2022. Link

Published Papers: 2015-present

36. Protein Condensate Formation via Controlled Multimerization of Intrinsically Disordered Sequences
Garabedian M.V., Su Z., Dabdoub J.B., Tong, M., Deiters A., Hammer D.A., Good M.C.*
Biochemistry, 2022. PDF. Link

35. Peeking Under the Hood of Early Embryogenesis: Using Tools and Synthetic Biology to Understand Native Control Systems and Sculpt Tissues.
Qian, W., Good, M.C.*
In Press, ​Seminars in Cell and Developmental Biology. 2022. PDF. Link

34. Assembly of a Light-Emitting Enzymatic Reaction into Model Protein Condensates
Guan M., Garabedian M.V., Leutenegger M., Schuster B.S., Good, M.C., Hammer, D.A.
Biochemistry (2021) 60: 3137-3151. doi: 10.1021/acs.biochem.1c00373. PDF. Link

33. Designer Membraneless Organelles Sequester Native Factors for Control of Cell Behavior
Garabedian M.V., Wang W., Dabdoub J.B., Tong, M., Caldwell R.M., Benman W., Schuster B.S., Deiters A., Good, M.C.*
Nature Chemical Biology  (2021). 17: 998-1007. DOI: 10.1038/s41589-021-00840-4. PDF. Link.
News, Views. Highlight. News. Modus Operandi

32. OptoLRP6 Illuminates Wnt Signaling in Early Embryo Development
Garabedian M.V., Good M.C.*  
Journal of Molecular Biology  (2021). PDF. Link.



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31. Patterning Microtubule Network Organization Reshapes Cell-Like Compartments​
Bermudez, J.G., Deiters A., Good, M.C.*  
ACS Synthetic Biology  (2021). PDF. Link.



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30. Integrating Cellular Dimensions with Cell Differentiation During Early Development
Chen, H., Qian, W., Good, M.C.*  
Current Opinion in Cell Biology 67: 109-117 (2020). PDF. Link.


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29. A C. elegans Zona Pellucida domain protein functions via its ZPc domain
Cohen J.D., Bermudez J.G., Good M.C., Sundaram M.V.
PLoS Genetics  16: e1009188 (2020).


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28. Nuclear sizER in Early Development
Chen, H., Good, M.C.*
Developmental Cell  54: 297-298 (2020). ​PDF.



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27. Imaging Nascent Transcription in Wholemount Vertebrate Embryos to Characterize Zygotic Genome Activation
Chen, H., Good, M.C.*
Methods In Enzymology  638: 139-165​ (2020). PDF. Link.



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26. Identifying Sequence Perturbations to an Intrinsically Disordered Protein that Determine Its Phase Separation Behavior
Schuster B.S., Dignon G.L., Tang W.S., Kelley F.M., Ranganath A.K., Jahnke C.N., Simpkins A.G., Regy R.M., Hammer D.A., Good M.C., Mittal J
PNAS  117: 1421-11431 (2020). PDF. Link.


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​25. Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms. 
Li, S., Xia, B., Javed, B., Hasley, W.D., Melendez-Davila, A., Liu, M., Kerzner, M., Agarwal, S., Xiao, Q., Torre, P., Bermudez, J.G., Rahimi, K., Kostina, N.Y., Möller, M., Rodriguez-Emmenegger,C., Klein, M.L., Percec, V.* and Good, M.C.* 
ACS Nano  14: 7398-7411 (2020)​. PDF. Link.
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24. SPLIT: Stable Protein Coacervation Using a Light Induced Transition
Reed, E.H., Schuster, B.S., Good, M.C., Hammer, D.A.
ACS Synthetic Biology  9:500-507 (2020). PDF. Link.





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23. Spatiotemporal Patterning of Zygotic Genome Activation in A Model Vertebrate Embryo
Chen, H., Einstein, L.C., Little, S., Good, M.C.*
​Developmental Cell  49: 852-866 (2019). PDF. Link. Supp. News





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22. Encapsulation of Hydrophobic Components in Dendrimersomes and Decoration of their Surface with Proteins and Nucleic Acids
Torre, P., Xiao, Q., Buzzacchera, I., Sherman, S.E., Rahimi, K., Kostina, N.Y., Rodriguez-Emmenegger, C., Möller, M., Wilson, C.J., Klein, M.L.*, Good, M.C.*, Percec, V.*
PNAS  116(31):15378-15385 (2019). PDF. Link. News.

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21. Encoding Biological Recognition In A Bicomponent Cell-Membrane Mimic
Rodriguez-Emmenegger C., Xiao Q., Kostina N.Y., Sherman S.E., Rahimi K., Partridge B.E., Li S., Sahoo D., Reveron Perez A.M., Buzzacchera I., Han H., Kerzner M., Malhotra I., Möller M., Wilson C.J., Good M.C., Goulian M., Baumgart T., Klein M.L., Percec V.
PNAS  116: 5376-5382 (2019).
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20. Cell Parts to Complex Processes, From the Bottom Up
Good M.*, Trepat X.*
Nature 563(7730): 188-189 (2018). PDF. Link





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19. Controllable Protein Phase Separation and Modular Recruitment to Form Responsive Membraneless Organelles
Schuster, B.S., Reed, E.H., Parthasarathy, R., Jahnke, C.N., Caldwell, R.M., Bermudez J.G., Ramage H.R., Good, M.C.* and Hammer, D.A.* 
Nature Communications 9:2985 (2018). PDF. Link

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18. Optochemical Control of Protein Localization and Activity Within Cell-Like Compartments
Caldwell R.M.#, Bermudez J.G.#, Thai D., Aonbangkhen C., Schuster B.S., Courtney T., Deiters A., Hammer D.A., Chenoweth D.M., and Good M.C.*
Biochemistry  57, 2590-2596 (2018). PDF. Pubmed
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17. Preparation of Cellular Extracts from Xenopus Eggs and Embryos
Good M.C.*, Heald R.*
Cold Spring Harbor Protocols  (2018). PDF. Pubmed
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16. Probing the Biology of Cell Boundary Conditions Through Confinement of Xenopus Cell-Free Cytoplasmic Extracts
Bermudez J.G., Chen H., Einstein L.C., Good M.C.*
Genesis  55 (1-2) (2017). PDF.  Pubmed
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15. Size Regulation: Big Insights from Little Cells
Chen H., and Good M.C.*
Developmental Cell  37, 392-394 (2016). PDF.  Pubmed
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14. Encapsulation of Xenopus Egg and Embryo Extract Spindle Assembly Reactions In Synthetic Cell-like Compartments with Tunable Size
Good M.C.*
Methods in Molecular Biology   1413, 87-108 (2016). PDF.  Pubmed

13. Turn Up the Volume: Uncovering Nucleus Size Control Mechanisms
Good M.C.*
Developmental Cell  33, 496-497 (2015).  PDF.  Pubmed

Previous Publications

12. A Comparative Analysis of Spindle Morphometrics across Metazoans
AUTHORS:  Crowder, M.E., Strzelecka, M., Wilbur, J.D., Good, M.C., von Dassow, G., and Heald, R.
Current Biology  25, 1542-1550 (2015).   PDF.  Pubmed   
 

11. Cytoplasmic Volume Modulates Spindle Size During Embryogenesis
AUTHORS:  Good, M.C., Vahey, M.D., Skandarajah, A., Fletcher, D.A., and Heald, R.
Science  342, 856-860 (2013).  PDF.  Pubmed

10. Scaffold proteins: hubs for controlling the flow of cellular information
AUTHORS:  Good, M.C., Zalatan, J.G., and Lim, W.A. 
Science  332, 680-686 (2011).  PDF.  Pubmed

9. Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB
AUTHORS:  Lombana, T.N., Echols, N., Good, M.C., Thomsen, N.D., Ng, H.L., Greenstein, A.E., Falick, A.M., King, D.S., and Alber, T. 
Structure  18, 1667-1677 (2010).  PDF.  Pubmed

8. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
AUTHORS:  Mok, J., Kim, P.M., Lam, H.Y., Piccirillo, S., Zhou, X., Jeschke, G.R., Sheridan, D.L., Parker, S.A., Desai, V., Jwa, M., Cameroni, E., Niu, H., Good, M., Remenyi, A., Ma, J.L., Sheu, Y.J., Sassi, H.E., Sopko, R., Chan, C.S., De Virgilio, C., Hollingsworth, N.M., Lim, W.A., Stern, D.F., Stillman, B., Andrews, B.J., Gerstein, M.B., Snyder, M., and Turk, B.E.  
Science Signaling  3, ra12 (2010).  PDF.  Pubmed

7. The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
AUTHORS:  Good, M., Tang, G., Singleton, J., Remenyi, A., and Lim, W.A.
Cell  136, 1085-1097 (2009).  PDF.  Pubmed

6. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
AUTHORS:  King, N., Westbrook, M.J., Young, S.L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., Marr, M., Pincus, D., Putnam, N., Rokas, A., Wright, K.J., Zuzow, R., Dirks, W., Good, M., … and Rokhsar, D. 
Nature  451, 783-788 (2008).  PDF.  Pubmed

5. Docking interactions in protein kinase and phosphatase networks
AUTHORS:  Remenyi, A., Good, M.C., and Lim, W.A. 
Current Opinion in Structural Biology  16, 676-685 (2006).  PDF.  Pubmed

4. The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.
AUTHORS:  Bhattacharyya, R.P., Remenyi, A., Good, M.C., Bashor, C.J., Falick, A.M., and Lim, W.A.
Science  311, 822-826 (2006).  PDF.  Pubmed

3. The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network
AUTHORS:  Remenyi, A., Good, M.C., Bhattacharyya, R.P., and Lim, W.A. 
Molecular Cell  20, 951-962 (2005).  PDF.  Pubmed

2. Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller
AUTHORS:  Good, M.C., Greenstein, A.E., Young, T.A., Ng, H.L., and Alber, T.
Journal of Molecular Biology  339, 459-469 (2004).  PDF.  Pubmed

1. An alternate conformation and a third metal in PstP/Ppp, the M. tuberculosis PP2C-Family Ser/Thr protein phosphatase
Pullen, K.E., Ng, H.L., Sung, P.Y., Good, M.C., Smith, S.M., and Alber, T.
Structure  12, 1947-1954 (2004).  PDF.  Pubmed

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