PUBLICATIONS

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2015 - Present (U.Penn)

Spatiotemporal Patterning of Zygotic Genome Activation in A Model Vertebrate Embryo
Chen, H., Einstein, L.C., Little, S., Good, M.C.*
​Developmental Cell 49 852-866 (2019). PDF. Link

Encapsulation of Hydrophobic Components in Dendrimersomes and Decoration of their Surface with Proteins and Nucleic Acids
Torre, P., Xiao, Q., Buzzacchera, I., Sherman, S.E., Rahimi, K., Kostina, N.Y., Rodriguez-Emmenegger, C., Möller, M., Wilson, C.J., Klein, M.L.*, Good, M.C.*, Percec, V.*
PNAS. In press (2019). 

Cell Parts to Complex Processes, From the Bottom Up
Good M.*, Trepat X.*
Nature 563(7730): 188-189 (2018). PDF. Link

Controllable Protein Phase Separation and Modular Recruitment to Form Responsive Membraneless Organelles
AUTHORS: Schuster, B.S., Reed, E.H., Parthasarathy, R., Jahnke, C.N., Caldwell, R.M., Bermudez J.G., Ramage H.R., Good, M.C.* and Hammer, D.A.* 
Nature Communications 9:2985 (2018). PDF. Link
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Optochemical Control of Protein Localization and Activity Within Cell-Like Compartments
AUTHORS: Caldwell R.M.#, Bermudez J.G.#, Thai D., Aonbangkhen C., Schuster B.S., Courtney T., Deiters A., Hammer D.A., Chenoweth D.M., and Good M.C.*
Biochemistry 57, 2590-2596 (2018). PDF. Pubmed
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Preparation of Cellular Extracts from Xenopus Eggs and Embryos
AUTHORS:  Good M.C.*, Heald R.*
Cold Spring Harbor Protocols (2018). PDF. Pubmed
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Probing the Biology of Cell Boundary Conditions Through Confinement of Xenopus Cell-Free Cytoplasmic Extracts
AUTHORS:  Bermudez J.G., Chen H., Einstein L.C., Good M.C.*
Genesis 55 (2017). PDF.  Pubmed

Size Regulation: Big Insights from Little Cells
AUTHORS:  Chen H., and Good M.C.*
Developmental Cell  37, 392-394 (2016). PDF.  Pubmed
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Encapsulation of Xenopus Egg and Embryo Extract Spindle Assembly Reactions In Synthetic Cell-like Compartments with Tunable Size
AUTHORS:  Good M.C.*
Methods in Molecular Biology  1413, 87-108 (2016). PDF.  Pubmed

Turn Up the Volume: Uncovering Nucleus Size Control Mechanisms
AUTHORS:  Good M.C.*
Developmental Cell  33, 496-497 (2015).  PDF.  Pubmed

Previous Publications

A Comparative Analysis of Spindle Morphometrics across Metazoans
AUTHORS:  Crowder, M.E., Strzelecka, M., Wilbur, J.D., Good, M.C., von Dassow, G., and Heald, R.
Current Biology  25, 1542-1550 (2015).   PDF.  Pubmed   
 

Cytoplasmic Volume Modulates Spindle Size During Embryogenesis
AUTHORS:  Good, M.C., Vahey, M.D., Skandarajah, A., Fletcher, D.A., and Heald, R.
Science  342, 856-860 (2013).  PDF.  Pubmed

Scaffold proteins: hubs for controlling the flow of cellular information
AUTHORS:  Good, M.C., Zalatan, J.G., and Lim, W.A. 
Science  332, 680-686 (2011).  PDF.  Pubmed

Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB
AUTHORS:  Lombana, T.N., Echols, N., Good, M.C., Thomsen, N.D., Ng, H.L., Greenstein, A.E., Falick, A.M., King, D.S., and Alber, T. 
Structure  18, 1667-1677 (2010).  PDF.  Pubmed

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
AUTHORS:  Mok, J., Kim, P.M., Lam, H.Y., Piccirillo, S., Zhou, X., Jeschke, G.R., Sheridan, D.L., Parker, S.A., Desai, V., Jwa, M., Cameroni, E., Niu, H., Good, M., Remenyi, A., Ma, J.L., Sheu, Y.J., Sassi, H.E., Sopko, R., Chan, C.S., De Virgilio, C., Hollingsworth, N.M., Lim, W.A., Stern, D.F., Stillman, B., Andrews, B.J., Gerstein, M.B., Snyder, M., and Turk, B.E.  
Science Signaling  3, ra12 (2010).  PDF.  Pubmed

The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
AUTHORS:  Good, M., Tang, G., Singleton, J., Remenyi, A., and Lim, W.A.
Cell  136, 1085-1097 (2009).  PDF.  Pubmed

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
AUTHORS:  King, N., Westbrook, M.J., Young, S.L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., Marr, M., Pincus, D., Putnam, N., Rokas, A., Wright, K.J., Zuzow, R., Dirks, W., Good, M., … and Rokhsar, D. 
Nature  451, 783-788 (2008).  PDF.  Pubmed

Docking interactions in protein kinase and phosphatase networks
AUTHORS:  Remenyi, A., Good, M.C., and Lim, W.A. 
Current Opinion in Structural Biology  16, 676-685 (2006).  PDF.  Pubmed

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.
AUTHORS:  Bhattacharyya, R.P., Remenyi, A., Good, M.C., Bashor, C.J., Falick, A.M., and Lim, W.A.
Science  311, 822-826 (2006).  PDF.  Pubmed

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network
AUTHORS:  Remenyi, A., Good, M.C., Bhattacharyya, R.P., and Lim, W.A. 
Molecular Cell  20, 951-962 (2005).  PDF.  Pubmed

Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller
AUTHORS:  Good, M.C., Greenstein, A.E., Young, T.A., Ng, H.L., and Alber, T.
Journal of Molecular Biology  339, 459-469 (2004).  PDF.  Pubmed

An alternate conformation and a third metal in PstP/Ppp, the M. tuberculosis PP2C-Family Ser/Thr protein phosphatase
Pullen, K.E., Ng, H.L., Sung, P.Y., Good, M.C., Smith, S.M., and Alber, T.
Structure  12, 1947-1954 (2004).  PDF.  Pubmed

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